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In addition, consistent with our current knowledge of intestinal FXR signaling and our hypothesis, the GLP-1 production was increased, while the glucose metabolism was improved in MMI-treated IFXRKO mice as compared to MMI-treated Floxed mice (Fig
Simonsen, F
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( AF ) Intracellular cAMP accumulation was measured in low-density human GIPR- and GLP-1Rexpressing HEK293 cells
69 Pegozafermin, a long-acting glycopegylated FGF21 analog, demonstrated improvement in liver fibrosis in MASH as shown in a 24-week phase 2B clinical trial (NCT04929483)
10.1017/S1461145704004596 38
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